Way Faster and Much More Furious

Apr 3, 2024

By the time you’ve read this sentence, we imagine that another Fast & Furious sequel starring Vin Diesel as main character, Dominic Toretto, and some super cool muscle cars will have been made. Just kidding. Sort of.

We read that 2025 will see the release of Fast & Furious 11, the twelfth film overall and reportedly, according to Vin Diesel, the last – haha, funny, yeah right! 😂 Since these movies feature cars and Mr. Diesel, we should probably talk about a VIN number. Another joke…😂😂

To put that VIN number in some context, by the time you finish reading this sentence, around 10,000 sequels (or virions) of AdAPT-001, an oncolytic adenovirus that infects tumors and expresses a transforming growth factor-beta (TGF-β) trap, will have been made. This is known as the viral burst size. That’s how many AdAPT-001 adenoviruses are approximately released per tumor cell. Multiply 10,000 by a million, which is how many cells that a tumor typically contains, (even though, admittedly, AdAPT-001 does not infect even close to every single tumor cell) and you have, well, an astronomical number.

Now multiply this astronomical number yet again by another million or so on the assumption that AdAPT-001 virions escape into the bloodstream, causing viremia, and infect one or more metastases. That is what we call exponential release – in just one patient, which probably explains the impressive examples of tumor shrinkage that we have seen in the ongoing Phase 2 clinical trial with AdAPT-001. If (or rather when, in our hopeful opinion) AdAPT-001 is approved, this same exponential release will occur in the millions or billions of patients that receive it to treat their cancer.

Another metric of comparison: the Fast & Furious franchise released a new sequel every 2 years or so. The rate at which AdAPT-001 produces new sequels (or virions) is approximately 2 days or so.

Hate to break it to you, Vin Diesel, but no matter how many sequels you ultimately make, and no one really believes you will ever stop at (only!) 12, what AdAPT-001 does is, let’s be honest, Way Faster & Much, Much More Furious.