The Road House Rules of RRx-001 (Nibrozetone) and AdAPT-001

Mar 12, 2024

© Metro-Goldwyn-Mayer Studios Inc. All Rights Reserved.

A remake of the 1989 unapologetically over-the-top cult classic, “Road House”, is set to drop on Amazon in late March.

To which we say, “awesome!” and “seriously can’t wait!”.

The original Road House, a modern-day Western, has it all: a hellhole bar named the Double Deuce, a virtuoso blind lap guitarist that plays behind a chicken wire cage to protect himself from the knife-wielding, bottle-throwing Double Deuce patrons, brawl after brawl in and out of the bar, enormous explosions, a great soundtrack, throwaway one-liners, a monster truck that demolishes a car dealership, random quotations from Western philosophers, a leggy blond doctor (Kelly Lynch), an aging mentor with a man-bun (Sam Elliott), a sadistic villain (Ben Gazzara), a hard-as-nails henchman (Marshall Teague), and a well-oiled Patrick Swayze as a Shane-like drifter with a philosophical bent who metes out rough justice according to a simple code of conduct: 1. Never underestimate your opponent; 2. Take it outside; 3. Be nice… until it is time not to be nice.

EpicentRx lead therapies, RRx-001 (nibrozetone), and AdAPT-001, adhere strictly to Rule Number 3: Be nice… not to tumors, but to normal tissues.

Potential proof of their “niceness” to normal tissues comes from a Phase 2b clinical trial called PREVLAR where RRx-001 (nibrozetone) prevented or mitigated the development of severe oral mucositis in first-line head and neck cancer, and from a Phase 1/2 clinical trial called BETA PRIME where AdAPT-001 may have dramatically reduced the risk of autoimmune toxicities from a concurrently administered checkpoint inhibitor.

Potential proof of their “not niceness” to tumors comes from several preclinical experiments and clinical trials – one of them in small cell lung cancer (SCLC) called REPLATINUM for RRx-001 and one of them in sarcoma for AdAPT-001 – where both therapies have demonstrated cytotoxic activity as single agents and in combination with other agents.

Critics – what do they know anyway, which is why we thumb our noses at them – reportedly hated Road House when it first came out in 1989 – one of them called it “Outhouse”.

These critics panned the many deep insights from the movie like “nobody ever wins a fight”, which a stoic Patrick Swayze tells his soon-to-be doctor girlfriend, a bespectacled and benighted Kelly Lynch, in the emergency room as she sews up his knife wound sans anesthetic.

However, for the sake of our clinical trial cancer patients let’s hope that RRx-001 (nibrozetone) and AdAPT-001 manage to win theirs convincingly – and nicely.