The Number One Impersonator

Jun 6, 2024

Maybe the second-best impersonator that we’ve ever seen is Frank Caliendo, who sounds like a dead ringer for a whole host of celebrities and sports personalities such as Charles Barkley, John C. Reilly, Robert Downey Jr., Joe Rogan, Chris Berman, Jon Gruden, Adam Sandler, Jeff Goldblum, Donald Trump, Stephen A. Smith, Al Pacino, Morgan Freeman, John Madden, and Joe Biden, as shown in the clickable videos below. The list goes on and on. Seriously, #Caliendo is a once-in-a-generational talent, like master impersonator, the man of one-thousand voices, #RichLittle, was in his day.

Impressions of: Morgan Freeman, Madden and Joe Biden

Still, hate to say it, but Frank Caliendo is not the best impersonator out there.

An even better one – and not by a little but by a lot?

Cancer cells.

These cells manage to impersonate or “spoof” normal cells to a such a degree that the immune system, which patrols the body specifically in search of “bad guys”, essentially mistakes them for self and stands down—much to the detriment of patients whose lives are often cut short because of it.

Lead anticancer agent, AdAPT-001, unmasks this rank impersonation through infection of tumor cells and expression of a transforming growth factor-beta (TGF-β) trap, which binds to and neutralizes the immunosuppressive protein or cytokine that many tumors overexpress, TGF-β. Clinical trial data suggest that this unmasking increases when AdAPT-001 is combined with a checkpoint inhibitor.

Which is great for patients and “turrible, just turrible” for cancer cells, as Charles Barkley/Frank Caliendo might say in the above link starting at 0:38 seconds.