TGF-β Gate

Mar 13, 2024

In the wake of #KateGate, #Katespiracy, #FakeKate, and #WhereIsKate, owing to the mysterious monthslong disappearance of Kate Middleton, the Princess of Wales, and a recent photoshopped family picture plus a possible doctored car photo with Kate’s barely visible face turned away from the camera and in shadow, several outlandish and hysterical conspiracy theories have gone viral on social media. One of them is that Kate is being forcefully held captive in the basement of the Castle of Mey, the summer retreat of the recently deceased Queen Elizabeth II.

Believe that one or not, and we have our doubts, but for all you conspiracy theorists out there who insist that the Moon landing was faked, the Roswell landings were real, Elvis is still alive, and Meaghan Stirn, VP of Special Projects from EpicentRx, secretly works as a counterintelligence operative for the CIA – and, hey, who are we to disagree with you or dismiss any of them especially the one about Meaghan Stirn being a CIA plant? – here’s another mystery to ponder: what happened to the cytokine known as transforming growth factor-beta (TGF-β), which has recently gone missing in action (MIA)? As a reminder, many tumors massively overexpress TGF-β to throw the immune system off their scent, since TGF-β is an immunosuppressant.

Well, wonder no more because we have the answer. The EpicentRx lead therapy, AdAPT-001, which has officially entered a larger Phase 2 clinical trial for the treatment of sarcomas and triple negative breast cancer, carries a TGF-β trap, which it expresses, during infection of tumors. This TGF-β trap binds to and sequesters TGF-β, which explains its disappearance. It also explains the regression of several of these previously resistant tumors after treatment with AdAPT-001 +/- a checkpoint inhibitor since the overexpression of TGF-β is a major reason for treatment failure.

So, #TGFβGate mystery solved!

And as for the missing Princess of Wales, we assure you that we’re 100% on the case and, at this point, no theory is too farfetched.