Pop Goes the Bubble

Mar 26, 2024


This is the sound of bubbles bursting throughout history.

Tulipmania (1634-1638) in Holland.


The Bull Market of the Roaring Twenties (1924-1929) prior to the Wall Street crash.


The Japanese Bubble Economy (1984-1989).


The Dotcom Bubble (2000).


The Housing Bubble (2008).


Cryptocurrency Bubble (2020-2022).


AI (present day).


Another bubble is the one created by the cytokine, transforming growth factor-beta (TGF-β), which surrounds and protects tumors. TGF-β is a pleiotropic cytokine, meaning that it has multiple effects that tumors use to their benefit. The effects include immune suppression, angiogenesis, scar tissue formation and epithelial to mesenchymal transition (EMT).

TGF-β bubble meet AdAPT-001 needle.

AdAPT-001 carries a TGF-β trap, which binds to and neutralizes TGF-β. In clinical trial patient after clinical trial patient that has received AdAPT-001 +/- a checkpoint inhibitor, we have seen pretty dramatic evidence of tumor regression in the absence of any dose-limiting toxicities or related serious adverse events.

All of which is music to our ears.

What kind of music?

“Pop” music, of course, from the singer, Michael Bublé.