Nibrozetone (RRx-001) Is “Chemo-sabe”

Oct 11, 2023

In the Lone Ranger, the Native American, Tonto, calls the fictional masked former Texas Ranger who fought outlaws in the American Old West, “Kemo-sabe.”

To quote from Wikipedia, Kemosabe is “derived from gimoozaabi, an Ojibwe and Potawatomi word that may mean ‘he/she looks out in secret’” and “it (gimoozaabi) has been occasionally translated as ‘trusty scout’ (the first Lone Ranger TV episode, 1949) or ‘faithful friend.’”

As EpicentRx CEO, Dr. Tony Reid, recently pointed out, nibrozetone (RRx-001) is “Chemo-sabe”, the faithful friend, that is administered with chemotherapy, radiation, and immunotherapy to potentially make them more active as well as safer and better tolerated.

In an upcoming Phase 2b randomized clinical trial called KEVLARx, nibrozetone (RRx-001) is compared to cisplatin and radiation and compared to cisplatin and radiation alone as a treatment of severe oral mucositis (SOM).

A previous 53 patient Phase 2a randomized clinical trial called PREVLAR demonstrated that nibrozetone (RRx-001) dramatically reduced the incidence and duration of SOM as well as increased the time to onset.

Nibrozetone (RRx-001) is also being given with platinum-based chemotherapy (cisplatin or carboplatin plus etoposide) in an ongoing Phase 3 clinical trial called REPLATINUM to treat small cell lung cancer (SCLC).

With the eternal cry of “Hi, ho, silver!”, the legendary Lone Ranger and his sidekick, Tonto, fought off bandits and imposed order on the lawless Old Wild West.

Likewise, to the accompaniment of “Hi, ho, platinum!”, we hope that nibrozetone (RRx-001), as a “Chemo-sabe” or “trusted friend”, will help to bring down cancer, the King of Bandits, on behalf of all the patients that it has victimized.