Love and Hate Relationship

Feb 14, 2024

This Valentine’s Day what better subject to tackle than love and hate, specifically as it applies to RRx-001 (nibrozetone), a small molecule we know so much about?

RRx-001 is a lover, the Romeo to the Juliet of normal tissues. As such, it protects them from all manner of cytotoxic insults such as radiation, chemotherapy, infections, and ischemia-reperfusion through several mechanisms including inhibition of the NLRP3 inflammasome and stimulation of the antioxidant transcription factor, Nrf2.

RRx-001 is also a villainous hater of diseased tissues, such as cancer, which it poisons instead of protects through the release of harmful metabolites like nitric oxide.

Love and hate are typically described as two sides of the same coin.

Or in this case two sides of the same small molecule.

Happy Valentine’s Day to you from all of us at EpicentRx❣