It’s Hip To Be Square

May 21, 2024

Chemical rings come in several different shapes.

Triangle-shaped 3-membered rings like cyclopropane.

Pentane-shaped 5-membered rings like cyclopentane.

Hexagon-shaped 6-membered rings like benzene, which because of its doughnut-like shape would undoubtedly appeal most to Homer Simpson and he would certainly reach for it if he could.

But Homer aside, we saved the best for last: square-shaped 4-membered rings like the dinitroazetidine in RRx-001 (nibrozetone), shown below.

Huey Lewis reportedly wrote the popular song, “Hip To Be Square,” in the late ‘80s about smoking cessation. However, he might well have written it about the EpicentRx lead candidate, RRx-001 (nibrozetone), which is both square and pretty hip if you ask us based firstly on where it comes from – the US aerospace industry, which no other drug can claim. And secondly because RRx-001 both treats diseased tissues like cancer, and protects normal ones like the skin, the oral mucosa, the heart, and the bone marrow during and after irradiation. So hip, so avant-garde, and so bright is the future of RRx-001 (nibrozetone), 🤞, that it should wear shades.

The band, Timbuk3, not Huey Lewis wrote “The Future’s So Bright, I Gotta Wear Shades”, but that song as well as “Hip To Be Square” are perfect anthems for RRx-001 (nibrozetone).