EpicentRx Word of the Week: Radiochemoprotection

Aug 7, 2023

“Mary, Mary quite contrary, please expand your vocabulary.”

Radiochemoprotection or Chemoradioprotection

Variation. Radiochemopretection or Chemoradiopretection


Noun: A term to describe the prevention or mitigation of the harmful effects of exposure to chemotherapy and radiation.

Radiochemoprotective/Chemoradioprotective adjective

Example sentences:

“Nibrozetone (RRx-001) was awarded FDA Fast Track designation for its radiochemoprotective properties.”

“Several indications would benefit from radiochemoprotection. These include locally advanced head and neck cancer, esophageal cancer, lung cancer, and rectal cancer.”


Radiochemoprotectors like nibrozetone (RRx-001) protect (or pretect) against radiation and chemotherapy injury when given prior to radiation and chemotherapy exposure. A radiochemomitigator protects against radiation and chemotherapy injury when given after exposure but prior to the development of symptoms. Radiochemoprotectors may improve quality of life for patients and the outcome of cancer treatment because of reduced damage to normal tissues. These compounds may also counteract the effects of accidental or deliberate exposure to radiation or chemotherapy from a nuclear reactor meltdown, dirty bomb, nuclear bomb explosion, or a gas attack; hence they are referred to as radiation countermeasures.

About the Word:

Radiochemoprotection (n.) is a compound word composed of radiotherapy, chemotherapy, and protection.