EpicentRx Word of the Week: NO

Jul 17, 2023

“The meek shall inherit…the Words of the Week.”



Noun: A colorless gas and a stable free radical that nibrozetone (RRx-001) generates at extremely high levels in hypoxic/reductive environments.

Example sentence:

NO laughing matter: NO, which stands for nitric oxide, is frequently mistaken for nitrous oxide or laughing gas.”


When nibrozetone (RRx-001) encounters an ischemic or hypoxic environment, it decomposes into several metabolites including NO or nitric oxide, which has several beneficial downstream effects on different disease processes from cancer to heart disease.

About the word:

From https://www.acs.org/molecule-of-the-week/archive/n/nitric-oxide.html

“Nitric oxide (NO) is a colorless gas and stable free radical that turns blue when it is liquefied or solidified. It was discovered and studied in 1772 by J. Priestley, who called it “nitrous air”. A toxic gas and air pollutant, NO has many industrial uses, especially in the production of nitric acid.

In the 1980s it was discovered that NO is the active metabolite released from nitroglycerine and amyl nitrite, vasodilators that are used for treating heart conditions such as angina. R. F. Furchgott, L. J. Ignarro, and F. Murad won the 1998 Nobel Prize in Physiology or Medicine for their work on NO’s role as a physiological signaling molecule. NO is released by the noni plant (Morinda citrifolia), which has been used as a “cure-all” by Pacific islanders for thousands of years.”