EpicentRx is a patient-driven immuno-oncology company with minimally toxic therapies that work across diverse patient populations and tumor types for the best possible quality of life during treatment. Through two complementary technology platforms that each activate and mobilize a different half of the immune system, innate (non-specific) and adaptive (specific) immunity, the company is developing drug candidates that are specifically toxic to tumor cells, not normal cells.
EpicentRx’s lead program, RRx-001, has been tested in several clinical trials including an ongoing Phase 3 study in small cell lung cancer. It is among a portfolio of small molecule compounds that favorably alter the tumor microenvironment, down-regulating CD47 and activating tumor associated macrophages (TAMs).
The company is also advancing multiple products through its AdAPT Platform, built around a next generation viral vector (TAV-255), highlighted by the clinical stage AdAPT-001, designed to selectively infect tumors and activate the immune system. In addition TAV-255 is being used for development of personalized cancer vaccines, designed to express cancer specific neoantigens to drive immune activation.
TONY REID, M.D. Ph.D.
Chief Executive Officer & Chief Scientific OfficerDr. Tony Reid, Chief Executive Officer and Chief Scientific Officer, holds a PhD focused in Antiviral and Antitumor Activity from Stanford. Reid further pursued his MD at Stanford focusing on targeted viral vector for cancer therapy and histone deacetylase inhibitors. In addition to his role at EpicentRx, Reid continues his 13 years as a Professor of Medicine at the University of California San Diego Moores Cancer Center as a medical oncologist focused on early phase clinical research while simultaneously developing an adenoviral platform. Dr. Reid holds numerous national awards such as America’s Top Doctor (top 1%), 2008 to present, America’s Top Doctor for Cancer (top 1%), 2009 to present, and America’s Most Honored Professional (top 1%), 2016 to present.
FRANCK BRINKHAUS, Ph.D.
Chief Financial OfficerDr. Brinkhaus serves as EpicentRx Chief Financial Officer and has experience in strategic advice, corporate finance and capital raising for life science companies. He is CEO & Founder of Biotech Alliances International, Inc., a Silicon Valley-based life sciences investment bank. Previously, Dr. Brinkhaus was Managing Director of Palo Alto-based Woodside Capital Partners. He holds a Master’s degree and a Ph.D. in Economics.
BRYAN ORONSKY, M.D. Ph.D.
Chief Medical OfficerDr. Oronsky serves as EpicentRx Chief Medical Officer and combines first hand clinical experience with 17 years of pharmaceutical development experience. Before joining EpicentRx, Dr. Oronsky worked as a Medical Officer at Intarcia Therapeutics. He has published over 100 peer-reviewed scientific articles, reviews and book chapters. He is also co-inventor of 10 issued patients and over 50 pending patents in the biomedical and device fields. Dr. Oronsky was educated at Princeton University, Catholic University in Belgium and University of Miami Medical School.
CHRIS LARSON, M.D. Ph.D.
Vice President of Viral Therapy10+ years experience in protein & viral engineering. Developed & optimized the TGF-beta “trap” virus (AdAPT-001). Innovator of viral production technologies. After completing medical school at UT Southwestern and a research-track hematology/oncology fellowship at UC San Diego, Dr. Larson developed techniques to expand the versatility of the oncolytic viral platform and spearheaded the personalized virus manufacturing program.
MEAGHAN STIRN, M.B.A.
Controller & VP of Special Projects
Leads financial reporting, accounting, and related internal controls. Since joining in 2015, Meaghan has served various roles in clinical, corporate, and financial operations. Meaghan has over 15 years of experience in clinical research management, specializing in oncology and immunology. BA in Chemistry and a BS in Physiological Sciences from the University of Arizona and earned a MBA in Accounting from National University.
Sr. Director of Operations & Corporate Development
10 years experience in Clinical Program Development and Life Science Business Strategies. Responsible for Global Operations, working directly with the Executive Team and helps to drive business development by prioritizing opportunities, conducting diligence, and transacting business and collaboration opportunities. Mr. Caroen is a co-author on over 40 peer reviewed scientific publications and co-inventor on 3 pending patents.
Director of Regulatory AffairsGina Varner serves as the Director of Regulatory Affairs for EpicentRx, Inc. where she fosters relationships with regulatory agencies, provides regulatory guidance to team members, and oversees general quality and compliance. Prior to joining the EpicentRx team, Ms. Varner held various positions in clinical trials administration and regulatory affairs at the UC San Diego Moores Cancer Center where she led projects to increase efficiency through the implementation of computerized systems. As a cancer survivor, Ms. Varner is passionate about finding new and creative ways to approach personalized drug development. Outside of work, she spends most of her time hiking and camping in the beautiful southern Californian mountains and deserts. Ms. Varner holds a bachelor’s degree in Biology from Point Loma Nazarene University and a Master’s in Public Health from San Diego State University.
ARNOLD ORONSKY, Ph.D.
We recognize the passing of an exceptional leader and ground-breaking visionary who founded EpicentRx. Those fortunate to interact and learn from “Arnie” carry forward his wisdom and his legacy lives on. With utmost sympathy we share our sadness with friends, colleagues, and the family in the passing of Arnold Oronsky.