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IMMUNOTHERAPY: ONCOLYTIC VIRUSES

 

While the normal function of the immune system is to ”protect and serve”, tumors actively produce and promote a state of immune unresponsiveness or tolerance called anergy; however, with oncolytic adenoviruses, which preferentially lyse and kill cancer cells, releasing  tumor proteins or antigens and proinflammatory cytokines into the circulation this malignant ‘spell of enchantment’ is broken and the immune system is “deanergized” to seek out and destroy both local tumors and distant metastases.

VIMMUNE is a multi-mechanistic ‘made-to-order’ portfolio of adenovirotherapeutic candidates armed with immunostimulatory transgenes that not only rev up the immune system against tumors but also shut down multiple currently undruggable oncogenic pathways