About Entering Phase 3 RRx-001
A new class of anti-cancer therapy with the potential to convert “treatment-resistant” tumors into “treatment sensitive” tumors
First-generation therapies, which target “checkpoint inhibitors”, have revolutionized the treatment of cancer, but only a small set of patients derives benefit. One of the reasons that not all patients respond to treatment is the presence of myeloid-derived suppressor cells in the tumor microenvironment.
Multimechanistic RRx-001 is a first-in-class small molecule immunotherapeutic that targets the CD47 – SIRPα axis and repolarizes tumor associated macrophages (TAMs) and other immunosuppressive cells in the tumor microenvironment to an immunostimulatory phenotype.
RRx-001 can be used as monotherapy or in combination with chemotherapy, radiation therapy or immunotherapy as an anti-cancer therapy, which also protects normal tissues.
RRx-001 was recently granted orphan drug designation for SCLC and neuroendocrine cancer in the US by the FDA and for SCLC in Europe by the EMA.
For a full list of currently enrolling clinical trials featuring RRx-001 please visit our Clinical Trials page.
For further information about RRx-001 mechanism of action and research please refer to our publications page.
For general inquiries about RRx-001, please contact us at firstname.lastname@example.org.